By now, the lingering sensation of numbness is an experience most of the people have undergone at the dental office, post an injection of local anesthetic solution, most commonly for surgical or non-surgical extraction, followed by root canal procedure.
Once the local anesthesia has been administered in the oral tissues, the loss of sensation continues for anywhere between two to three hours (depending the amount given). Isn’t temporarily losing sensation in the mouth quite an unwanted, bothersome hassle, especially after the procedure has been done with?
Besides the benumb feeling, a person’s ability to communicate clearly, smile, chew and drink is marred for some time. Some may even find it difficult to control the drooling of saliva. However, such a long standing, unpleasant sensation may be your last one ever, courtesy, a revolutionary dental product which was introduced by Novalar Pharmaceuticals, Inc. in the recent past!
Using OraVerse, your dental care provider has found a safe and proven solution that may substantially accelerate the restoration of normal sensation in the soft tissues of the oral cavity after routine dental procedures.
OraVerse Anesthesia Reversal
All You Need to know about OraVerse
OraVerse is a trustworthy and efficacious form of Phentolamine mesylate, which works both as an anesthetic agent and a vasodilator. The drug, Phentolamine mesylate has been put to many medical uses since 1952. OraVerse is, in fact, the first and lone local anesthetic solution which brings patients back to their normal sensation within an extremely short span, almost twice as fast! The quick mode of action by which OraVerse nullifies the effect of local anesthesia gives people the chance to go ahead with their usual work after the dental appointment.
OraVerse as a Local Anesthetic Reversal Product
Clinical trials were carried out to establish the effectiveness and working time of OraVerse. It was observed that the average time span taken by the local anesthetic reversal agent to restore the normal sensation of the upper lip of patients was barely 50 minutes, as compared to the other group of patients (who did not receive OraVerse) which took roughly 133 minutes.
As for the lower lip, patients given OraVerse regained their usual sensation within 70 minutes whereas the control group took almost 155 minutes.
Mode of Action of OraVerse
OraVerse is given by a dental professional to nullify the numbing effect caused by an introral injection of local anesthesia, primarly in the tongue and lip region. The basic purpose is to shorten the lingering effect of local anesthesia once it has completely served its purpose. The precise mechanism pathway via which phentolamine mesylate hastens the reversal of soft tissue anesthetic drug coupled with associated functional impairement is not fully clear.
The above mentioned active ingredient of OraVerse works as a quick onset alpha adrenergic blocker which results in dilation of the blood vessels. It is believed that the product quickens the clearance rate of Lidocaine from the oral region into the systemic circulation. As the tissues are still numb from the injection, patients do not experience any discomfort whilst receiving a dose of OraVerse.
Who Stand to Gain from OraVerse
It is important to seek consultation from the dentist in order to determine whether or not an individual is a safe candidate for receiving OraVerse. Well controlled trials prove that the local anesthetic reversal agent can be administered to children at and above 6 years, having a body weight of above 33 pounds as well as adults. However, the efficacy of OraVerse in pediatric patients younger than 6 years has yet to be medically confirmed.
Relevant Safety Information Regarding OraVerse
The newly introduced OraVerse has already received approval from United States Food And Administration Drug (FDA). It is thus regarded completely safe and effectual for inhibiting the numbing action brought about by local anesthesia. Till now, a few studies have stated that OraVerse is not linked with life threatening adverse reactions or potent side effects.
On the other hand, a few trials show that certain reactions have been noticed with the use of phentolamine mesylate. These include post procedural discomfort, pain at the site of injection, headache and increase or drop in the rate of heart beat (tachycardia and bradycardia, respectively).
It is thus advisable for patients with a history of heart related disease or condition to mention so to their dentist. This is so because in excessively high doses, an intravenous injection of phentolamine can lead to myocardial infarction, hypotensive episodes or even cerebrovascular spasm. Even nursing or pregnant women must seek medical consultation before opting for OraVerse. Other than that, the use of OraVerse is considered safe.